NEW

Cradle raises $73m Series B

Protein engineering without the guesswork

Design improved variants of your target protein sequence with just a few clicks — and some machine learning.

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TRUSTED BY

Target protein sequence

MLCDLKQGEPICVQKERKTPRDSGQQCHACIJKMGGHQ

Stability

Activity

Generate variants

Bring lab data or start fresh

Get started by importing assay data from an ongoing project – or start fresh from just a single starting sequence.

No surprises in the lab

Each generated sequence comes with a predicted performance score. Less exciting for some, more productive for everyone.

Reach objectives in half the time

Cradle learns with every experimental round, giving you better variants each time – and dramatically cutting your time-to-market .

Optimize everything at once

Cradle lets you optimize multiple properties at once. You save time, the models learn faster. It’s a win-win.

Used by industry
leaders and #bioneers

The world’s leading biotech teams are using Cradle to accelerate new and ongoing projects – and to revisit challenging ones.

Multi-property.
No-problem.

Unlike traditional methods, Cradle is engineered to handle multiple properties and optimization tasks in a single round.

Enzymes

Vaccines

Peptides

Antibodies

Activity

Thermostability

Solvent stability

Solubility

Substrate specificity

E-coli expression

MSTASGVEEQVIVNYQDSKNGYKIIKKATLWAFNRGVDWKFYKYLRGKQTYQCDLKQGIGTINRPEPTIDESKGVTVLIKRYLNFNAKPMRYFEKLDEEPGDKTYVTVLKKNGRKVMMFNTGVYEYKYLSVHQTYFRLFVNSHGRSLSGQAYNFGRGVCYNDNFQKGYMNGRNSYENVAHIFCICGNVPEVACCINESMSTASGVEEQVIVNYQDSKNGEPICVQKESWLWEVTGPYRINYPDRKKQVVYYKEMTQHTAKGSFQATSVDRKTPRDSGQQGYPCCPIMKISQDWTDKAIFSENGVYVRNIGTINRKGVTVLIKRYLENZYMESNFNAKPMRYFEKLDEEPGDKTYVFRLFVNSHGRSLSGQAYNFGRGVCYNDNFQKGYMNGRNSYENVAHIFCICGNVPEMSTASGVEEQVIVNYQDSKNGYKIIKKATLWAFNRGVDWKFYKYLRGKQTYQCDLKQGEPICVQKESWLWEVTGPYRINYPDRKKTQATSVDRKTPRDSGQQGYPCCPIMKISQDWTMDDANTIBODIESKAIFSNVYVRNYKIIKKATLWAFNRGVDWKFYKYLRGKQTYQCDLKQGEPICVQKESWLWEVTGPYRINYPDRKKQVVQDWTDKAIFSENGVYVRNIG

Proteins are complicated.
Using Cradle is not.

We've designed Cradle to be as easy as possible to get started with – that means it fits right into your existing workflow.

Set up assays and objectives

Getting started is easy, just tell Cradle what you plan to measure and where you want those measurements to go for your project to be successful.

Generate sequences

Test in lab

Import lab results

Private. Secure. Yours.

With Cradle, your sequences and data are kept private and secure while giving you full ownership of all intellectual property.

Private by design

Only you and people you invite can access your sequences and experimental data. Your data is never used to train models for other users.

Safe & Secure

Cradle uses bank-grade level of security to keep your data safe.

Own your IP

You own your IP. Royalties? Nope. With Cradle you pay a flat fee per year for using our tools for your project.

PCCPIMKISQDWTDAATNMODREAKAIFSENGVYVRNYKIIKKATLWAFNRGVDWKFYKYLRGKQTYQCDLKQGEPICVQKESWLWE

QCDLKQGEPICVQKESWLWEVTGPYRINMSTASGVEEQVIVNYQDSKNGYKIIKKATLWAFNRGVDWKFYKYLRGKQTYQCDLKQGIGTINRPSQTIDLSKGVTVLIKRYLNFNAKPMRYFEKLDEEPGDKTYVTVLKKNGRKVMMFNTGVYEYKYLSVHQTYFRLFVNSHGRSLSGQAYNFGRGVCYNDNFQKGYMNGRNSYENVAHIFCICGNVPEMKTYVTVLKKNGRKVMMFNTGVYEYKYLSVHQTYFRLFVNSHGRSLSGQAYNFGRGVCVVQDWTDKAIFSENGVYVRNIGTINRKGVTVYYKEMTQHTAKGSFQATSVDYQCDLKQGEPICVQKESWLWEVTGPYRINMSTASGVEEQVIVNYQDSKNGYKIIKKATLWAFNRGVDWKFYKYLRGKQTYQCDLKQGIGTINRPSQTIDLSKGVTVLIKRYLNFNAKPMRYFEKLDEEPGDKTYVTVLKKNGRKVMMFNNFNAKPMRYFEKLDEEPGDKTYVTVLKKNGRKVMMFNTGVYEYKYL

RNIGTINRKGVTVYYKEMTQHTAKGSFQA

The team

At Cradle we believe biology can theoretically be used to produce almost anything, from therapeutics to chemicals, materials and food. Designing proteins is not easy, but with our tools and machine learning models we are changing that.

Meet the team

Careers